Steroids and derivatives
Medchemexpress LLC Bazedoxifene (acetate) | 198481-33-3 | 99.9% | C32H38N2O5 | 200 MG
Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. It can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.
- Oral, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM and 99 nM for ERα and ERβ
- Useful for the research of osteoporosis
- Acts as an inhibitor of IL-6/GP130 protein-protein interactions
- Useful for the research of pancreatic cancer
Medchemexpress LLC Eldecalcitol | 104121-92-8 | 99.9% | C30H50O5 | 5 MG
Eldecalcitol (ED-71) is an orally active vitamin D3 analogue that inhibits bone resorption and increases bone mineral density. It also exhibits an anti-tumor effect, inhibits cell proliferation, migration, and induces apoptosis by suppressing GPx-1.
- Orally active vitamin D3 analogue
- Inhibits bone resorption and increases bone mineral density
- Exhibits anti-tumor effects
- Inhibits cell proliferation and migration
- Induces apoptosis by suppressing GPx-1
- Shows no cytotoxicity at 0-50 nM for 24 hours
- Reduces cell death induced by LPS
- Inhibits LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1
- Arrests cell cycle at G0/G1 phase
- Stimulates focal bone formation and suppresses bone resorption
Medchemexpress LLC (24S)-24,25-Dihydroxyvitamin D3 | 55700-58-8 | C27H44O3 | 5 MG
(24S)-24,25-Dihydroxyvitamin D3 is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. It is an isomer of 24,25-dihydroxyvitamin D3. Vitamin D is metabolized in the liver to 25-hydroxyvitamin D3, and in the kidney to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.
- Inactive form of vitamin D3
- Undergoes hydroxylation to form active vitamin D3 analogs
- Isomer of 24,25-dihydroxyvitamin D3
- Metabolized in the liver to 25-hydroxyvitamin D3
- Metabolized in the kidney to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3
Medchemexpress LLC Hexanoylglycine-d2 | 1256842-52-0 | 175.22 | 100 MG
Hexanoylglycine-d2 | 1256842-52-0 | 175.22 | 100 MG
Medchemexpress LLC Propyphenazone-d3 | 162935-29-7 | 99.0% | C14H15D3N2O | 1 MG
Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity. Propyphenazone-based analogues act as proagents and selective cyclooxygenase-2 inhibitors. It is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC ACTH (11-24) acetate | 99.88% | 1652.04 | 10 MG
ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. It is a fragment of adrenocorticotropic and induces cortisol release. This compound can be used for research of the central nervous system. In vitro, ACTH (11-24) (acetate) elicits cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells, and in vivo, it has slight influences on circulating plasma corticosterone values and on fighting behavior.
- Adrenocorticotropic hormone (ACTH) receptor antagonist
- Induces cortisol release
- Suitable for research of the central nervous system
- Purity of 99.88%
- Molecular weight of 1652.04 (free base)
Medchemexpress LLC Bazedoxifene (acetate)-D | 198481-33-3 | 99.9% | C32H38N2O5 | 50 MG
Bazedoxifene (acetate)-D is the D-crystal form compound of Bazedoxifene acetate, an orally active, nonsteroidal selective estrogen receptor modulator (SERM) with IC50s of 23 nM for ERα and 99 nM for ERβ.
- D-crystal form compound
- Orally active, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM for ERα and 99 nM for ERβ
- Purity of 99.9%
- Molecular weight of 530.65
- Chemical formula: C32H38N2O5
- CAS number: 198481-33-3
- Appears as a solid
- Color is white to off-white
- Soluble in DMSO at 50 mg/mL
Enzo Life Sciences 20-Hydroxyecdysone (10mg). CAS: 5289-74-7
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of Drosophila melanogaster. Alternative name: beta-Ecdysone, 2beta,3beta,14alpha,20R,22R,25-Hexahydroxy-5beta-cholest-7-en-6-one, Ecdysterone. Purity: ≥95% HPLC. Solubility: Soluble in water, 100% ethanol, methanol, DMSO and acetic acid. Long Term Storage: -20°C.
Apexbio Technology LLC Estrone 53-16-7 10g
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases
TARGETMOL CHEMICALS INC 16alpha-Bromoepiandrosterone
Also available in 5 mg, 10 mg, 25 mg and bulk. Please contact Fisher for quotes. 16alpha-Bromoepiandrosterone (BEA) is a water-soluble synthetic sterol related to DHEA and is used in studies of type II diabetes and non-diabetic tuberculosis infections. Purity 98.99%
Medchemexpress LLC Bazedoxifene (acetate)-D | 198481-33-3 | MFCD09260074 | C32H38N2O5 | 100 MG
Bazedoxifene (acetate)-D is a solid compound with a molecular formula of C32H38N2O5 and a molecular weight of 530.65. It is classified as a selective estrogen receptor modulator and a bone density conservation agent. This compound helps to inhibit bone resorption and favor bone mineralization, making it suitable for addressing conditions like osteoporosis and promoting bone fracture healing. It is an FDA-approved, prescription-only drug administered orally.
- Functions as a selective estrogen receptor modulator
- Acts as a bone density conservation agent
- Inhibits bone resorption
- Promotes bone mineralization and regeneration
- Utilized in treating osteoporosis and healing bone fractures
- FDA-approved, available by prescription only
- Administered via oral route